Browsing by Subject "Blood vessels"

Now showing items 1-13 of 13

    • Conference Object  

      Abdominal Aortic Aneurysm medical video transmission 

      Panayides, Andreas S.; Antoniou, Zinonas C.; Barberis, Vassilis I. I.; Pattichis, Marios S.; Pattichis, Constantinos S.; Kyriacou, Efthyvoulos C. (2012)
      Abdominal Aortic Aneurysm (AAA) is responsible for approximately 1.3% of all deaths among men over the age of 65. Given the fact that once an aortic rupture occurs mortality rates are estimated between 80%-90%, national ...
    • Conference Object  

      De-speckle filtering in ultrasound imaging of the carotid artery 

      Christodoulou, Christodoulos I.; Loizou, Christos P.; Pattichis, Constantinos S.; Pantzaris, Marios C.; Kyriacou, Efthyvoulos C.; Pattichis, Marios S.; Schizas, Christos N.; Nicolaïdes, Andrew N. (2002)
      The main objective of this paper is to evaluate the classification performance of de-speckle filtering on ultrasound imaging of the carotid atherosclerotic plaque. The following procedure was investigated on 230 images ...
    • Article  

      Delivery of molecular and nanoscale medicine to tumors: Transport barriers and strategies 

      Chauhan, V. P.; Stylianopoulos, T.; Boucher, Y.; Jain, R. K. (2011)
      Tumors are similar to organs, with unique physiology giving rise to an unusual set of transport barriers to drug delivery. Cancer therapy is limited by nonuniform drug delivery via blood vessels, inhomogeneous drug transport ...
    • Article  

      Effect of head posture on the healthy human carotid bifurcation hemodynamics 

      Papaharilaou, Yannis; Aristokleous, Nicolas; Seimenis, Ioannis; Khozeymeh, M. I.; Georgiou, Georgios C.; Brott, B. C.; Eracleous, Eleni A.; Anayiotos, Andreas S. (2013)
      Head and neck postures may cause morphology changes to the geometry of the carotid bifurcation (CB) that alter the low and oscillating wall shear stress (WSS) regions previously reported as important in the development of ...
    • Article  

      The Effect of Head Rotation on the Geometry and Hemodynamics of Healthy Vertebral Arteries 

      Aristokleous, Nicolas; Seimenis, Ioannis; Georgiou, Georgios C.; Nicolaïdes, Andrew N.; Anayiotos, Andreas S. (2015)
      The geometric and hemodynamic characteristics of the left and right vertebral arteries (LVA, RVA) of six healthy volunteers were investigated for the supine (S) and the prone position (P) a common sleeping posture with ...
    • Article  

      Impact of head rotation on the individualized common carotid flow and carotid bifurcation hemodynamics 

      Aristokleous, Nicolas; Seimenis, Ioannis; Georgiou, Georgios C.; Papaharilaou, Yannis; Brott, B. C.; Nicolaïdes, Andrew N.; Anayiotos, Andreas S. (2014)
      This paper aims at evaluating the changes that head rotation poses on morphological and flow characteristics of the carotid bifurcation (CB) and on the distribution of parameters that are regarded as important in atherosclerosis ...
    • Conference Object  

      An integrated system for the assessment of ultrasonic imaging atherosclerotic carotid plaques 

      Pattichis, Constantinos S.; Christodoulou, Christodoulos I.; Pattichis, Marios S.; Pantzaris, Marios C.; Nicolaïdes, Andrew N. (2001)
      The objective of this work is to develop a system that will facilitate the automated characterization of ultrasonic imaging carotid plaques for the identification of individuals with asymptomatic carotid stenosis at risk ...
    • Conference Object  

      Mechanical stress regulates tissue oxygenation, cancer cell proliferation and drug delivery during progression of solid tumors 

      Mpekris, F.; Angeli, S.; Pirentis, A. P.; Stylianopoulos, T. (Springer Verlag, 2016)
      Oxygen supply plays a central role in cancer cell proliferation. While vascular density increases at the early stages of carcinogenesis, mechanical solid stresses developed during growth compress tumor blood vessels and, ...
    • Article  

      The role of mechanical forces in tumor growth and therapy 

      Jain, R. K.; Martin, J. D.; Stylianopoulos, T. (2014)
      Tumors generate physical forces during growth and progression. These physical forces are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. When exerted directly on cancer cells, ...
    • Article  

      The Solid Mechanics of Cancer and Strategies for Improved Therapy 

      Stylianopoulos, T. (2017)
      Tumor progression and response to treatment is determined in large part by the generation of mechanical stresses that stem from both the solid and the fluid phase of the tumor. Furthermore, elevated solid stress levels can ...
    • Article  

      Sonic-hedgehog pathway inhibition normalizes desmoplastic tumor microenvironment to improve chemo- and nanotherapy 

      Mpekris, F.; Papageorgis, P.; Polydorou, C.; Voutouri, C.; Kalli, M.; Pirentis, A. P.; Stylianopoulos, T. (2017)
      Targeting the rich extracellular matrix of desmoplastic tumors has been successfully shown to normalize collagen and hyaluronan levels and re-engineer intratumoral mechanical forces, improving tumor perfusion and chemotherapy. ...
    • Article  

      Stress-mediated progression of solid tumors: effect of mechanical stress on tissue oxygenation, cancer cell proliferation, and drug delivery 

      Mpekris, F.; Angeli, S.; Pirentis, A. P.; Stylianopoulos, T. (2015)
      Oxygen supply plays a central role in cancer cell proliferation. While vascular density increases at the early stages of carcinogenesis, mechanical solid stresses developed during growth compress tumor blood vessels and, ...
    • Article  

      Texture-based classification of atherosclerotic carotid plaques 

      Christodoulou, Christodoulos I.; Pattichis, Constantinos S.; Pantzaris, Marios C.; Nicolaïdes, Andrew N. (2003)
      There are indications that the morphology of atherosclerotic carotid plaques, obtained by high-resolution ultrasound imaging, has prognostic implications. The objective of this study was to develop a computer-aided system ...